Wnr IV
Methylcobalamin 1500mcg, Pyridoxine hcl- 100mg, Niacinamide- 100mg.
Diabetic Peripheral Neuropathic Pain
Clinical symptoms in legs, such as paresthesia, burning pains, and spontaneous pain, were ameliorated by MeCbl . The effects of single use of MeCbl or combined use with other drugs were reviewed in diabetic neuropathy pain. Clinical evidence proved that MeCbl had the capacity to inhibit the neuropathic pain associated with diabetic neuropathy.
Table 1
The analgesic effect of MeCbl or combined use with other drugs on patients with diabetic neuropathic pain.
| Effects of MeCbl | Indices | Measures of intervention | Reference |
|---|---|---|---|
| Alleviation of neuropathic pain symptoms; improved nerve conduction velocity |
Pain scale scores of patients; measure of nerve conduction velocity | Oral administration of MeCbl for 3 months | Devathasan et al. |
|
|
|||
| Improved nerve conduction velocity | Measure of nerve conduction velocity | Intravenous administration of MeCbl | Ishihara et al. |
|
|
|||
| Improved the symptoms of paresthesia, burning pains, and heaviness; no effect on nerve conduction velocity |
Pain symptoms; measure of nerve conduction velocity | Repeated intrathecal injection of MeCbl at a high dose of 2.5 mg/10 mL | Ide et al. |
|
|
|||
| Relieved spontaneous pain by 73% | Likert-type pain intensity scale; Patients' Global Impression of Change (PGIC) scale | Intramuscular injection of MeCbl for four weeks followed by oral administration of MeCbl for additional eight weeks | Li |
|
|
|||
| Relieved pain and paresthesia; improved motor and sensory nerve conduction velocity |
Neurolgical disability score for the grades of pain and paresthesia | Intravenous injection of MeCbl for 6 weeks | Kuwabara et al. |
|
|
|||
| Reduced pain scores and good tolerance | Visual analog scale and chemical safety | Oral administration of immediate-release methylcobalamin and sustained-release pregabalin for 2 weeks. | Dongre and Swami |
The intensity of the pain is variable and may be described as a hot, burning, cold, aching, or itching sensation with, at times, increased skin sensitivity. In clinics, it is still a challenge to treat diabetic neuropathic pain. Carbamazepine and dolantin were not able to relieve these symptoms. Similarly, therapeutic effects of aldose reductase inhibitors and nimodipine were not encouraging in clinic as much as basic studies showed. Fortunately, MeCbl may bring a glimmer of hope to treat diabetic neuropathic pain.
Low Back Pain
Between 70 and 80% adults have experienced low back pain at some times in their life. Back pain is one of the most common health complaints. But the causes are extensive, cancer, infection, inflammatory disorders, structural disorders of the spine itself, and disk herniation, are somewhat more common, and together account for back pain. It is supposed that the MeCbl is becoming a decent choice for the therapy to the chronic low back pain. Neurogenic claudication distance was improved significantly after the application of MeCbl . However Waikakul's research demonstrated that MeCbl was not good for pain on lumbar spinal stenosis . In a trial, the analgesic effect of MeCbl has been investigated in nonspecific low back pain patients with intramuscular injection. The inconsistent effect of MeCbl might be due to different causes of lumbar spinal stenosis and nonspecific low back pain. Further studies are needed to determine the effect of MeCbl on low back pain.
The analgesic effects of MeCbl on low back pain and neck pain in clinical trials.
| Effects of MeCbl | Indices | Measures of intervention | Reference |
|---|---|---|---|
| Relieved spontaneous pain, allodynia, and paresthesia. | Pain symptoms of patients with neck pain | Oral administration of MeCbl for 4 weeks | Hanai et al. |
|
|
|||
| Amelioration of neurogenic claudication distance; no effect on pain improvement and neurological signs | Pain symptoms; measure the neurogenic claudication distance of patients with degenerative lumbar spinal stenosis | Oral administration of MeCbl as an adjuvant medication for 6 months | W. Waikakul and S. Waikakul |
|
|
|||
| Reduced pain | Oswestry disability index questionnaire (ODI) and visual analogue scale (VAS) pain score of patients with nonspecific low back pain | Intramuscular injection of MeCbl for 2 weeks | Chiu et al. |
Neck Pain
Chronic neck pain is becoming a common problem in the adult population, for the prevalence of 30%–50% in 12 months . It was shown that spontaneous pain, allodynia, and paresthesia of patients with neck pain were improved significantly in the MeCbl group, and with the increase of treatment time of MeCbl, the analgesic effect was more obvious.
Neuralgia
Subacute Herpetic Neuralgia
The treatment of MeCbl significantly reduced continuous pain, paroxysmal pain, and allodynia in the subacute herpetic neuralgia (SHN) patients. Thus, MeCbl may be an alternative candidate for treating SHN.
The analgesic effect of MeCbl or combined with other agents on neuralgia.
| Effects of MeCbl | Indices | Measures of intervention | Reference |
|---|---|---|---|
| Reduced or eliminated pain symptoms | Pain scales in patients with trigeminal neuralgia | Intravenous injection of MeCbl at a single dose of 0.5 mg | Teramoto |
|
|
|||
| Relieved overall pain, continuous spontaneous pain, paroxysmal pain, and allodynia | Likert-type pain intensity scale; Patients' Global Impression of Change (PGIC) scale | Local subcutaneous injection of MeCbl for 4 weeks | Xu et al |
|
|
|||
| Lowered pain intensities; improved pain relief; reduced pain interference with quality of life | Numerical pain scale and brief pain inventory of glossopharyngeal neuralgia | Oral administration of gabapentin, tramadol, and MeCbl (0.5 mg) | Singh et al. |
Glossopharyngeal Neuralgia
Glossopharyngeal neuralgia (GPN) is a common facial neuralgia in the pain clinics. It was reported that the numerical pain scales were decreased substantially with the treatment of MeCbl combined with gabapentin and tramadol in GPN patients . And degree of interference in quality of life including mood, interpersonal relationship, and emotion was improved earlier.
Trigeminal Neuralgia
The pain of trigeminal neuralgia (TN) can be described as agonizing, paroxysmal and lancinating which may be activated by small activities such as chewing, speaking, and swallowing. A clinical trial proved that the pain of TN patients was alleviated greatly in the MeCbl group, and no recurrence of TN in pain symptoms was closed to 64%.
₹ 80